Home » Therapy » Depression » Clinical depression

It's important to remember that it's okay to have tough days. However, if you find it hard to enjoy things you used to like for more than two weeks, it's a good idea to seek help. Here, we will explain clinical depression and how you can get help.

Clinical depression

Clinical depression is a severe medical condition that negatively affects how a person feels, thinks and manages daily activities. Symptoms must have been present for at least two weeks for the diagnosis.

Clinical depression is more than just feeling down or sad for a short period; it is a persistent feeling of sadness and loss of interest that is different from usual mood swings. But it can be helped in therapy.

What set our therapist apart was her genuine empathy and personal insight. Not only did she possess a deep understanding of neurodiversity, but she also shared personal experiences that resonated with us, creating an instant connection and fostering a sense of trust!

Benedetta Osarenk


Our counsellors

Click here to view all psychologists, therapists, and coaches.

Why do people get depressed?

Depression is a complex illness that is often caused by a combination of genetic, biological, environmental and psychological factors. Family history suggests that heredity may play a role. Imbalances in brain neurotransmitters such as serotonin and dopamine, which affect mood and emotional stability, may be involved. Hormonal changes during pregnancy, the postpartum period, menopause or thyroid problems can trigger depression symptoms. Certain personality traits, such as low self-esteem and pessimism or increased sensitivity to stress, can make individuals more likely to develop depression.

Criteria for diagnosis

For a diagnosis of clinical depression to be made according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the individual must exhibit a combination of symptoms that affect their mood, bodily functions and thinking.


Book a meeting

Fill in the form, choose a counsellor, and proceed to payment.

They must experience a marked depressive mood or a significant loss of interest or pleasure in most activities almost every day for at least two weeks. In addition, the individual should have experienced considerable weight or appetite changes, sleep problems such as insomnia or excessive sleep, psychomotor agitation or inhibition that others notice. There is often a marked fatigue or loss of energy, feelings of worthlessness or unreasonable guilt. Depression can cause impaired ability to think, concentrate or make decisions, as well as recurrent thoughts of death, including suicidal thoughts without a specific plan, suicide attempts or an elaborate plan to commit suicide.

To meet the criteria for the diagnosis, at least five of these symptoms must be present, at least one of which must be either depressive mood or loss of interest or pleasure. These symptoms must lead to impairment in social, occupational, or other important areas of functioning, and they cannot be the result of medical conditions, substance use, or other mental health problems. They should also not be explained by grief, i.e. after the loss of a loved one, which can produce similar symptoms but is a normal reaction to grief.

Symptoms of clinical depression

The symptoms of clinical depression include several emotional, physical and cognitive signs that affect a person’s ability to function in everyday life. These include:

  • A persistent feeling of sadness or emptiness
  • Irritability which is present most of the day, almost every day
  • A marked decrease in enjoyment of daily activities
  • Significant weight loss/weight gain
  • Decreased/increased appetite
  • Insomnia or excessive sleep
  • Psychomotor agitation that is observable by others
  • Fatigue or loss of energy
  • Feelings of worthlessness or excessive, inappropriate guilt
  • Impaired ability to think, concentrate or make decisions
  • Recurrent thoughts of death (not just fear of dying)
  • Recurrent suicidal thoughts without a specific plan
  • A suicide attempt
  • A specific plan to commit suicide.

If you recognize these symptoms, seeking help from a qualified health professional to help with treatment is good. Depression is a treatable and recoverable condition.


Why Lavendla?

4,7 of 5 in 5000+ reviews

Thousands of clients trust Lavendla Therapy for delivering exceptional service and support.

Choose your own counsellor

Browse and select a counsellor based on reviews, area of focus, and education, ensuring you find the perfect match.

45, 60 or 90 min sessions

Choose a 45, 60, or 90-minute session, or a package, providing flexibility and control over the duration and intensity.

Subgroups of clinical depression

Within the framework of clinical depression, several subgroups help describe more specific forms of the illness. These subgroups can be helpful in better tailoring treatment to the patient’s unique needs and symptoms. Some of the most common subgroups are:

  1. Depression with anxiety symptoms: It is common to have both anxiety and depression. It is characterized by the presence of tension, worry, and a feeling that something bad is going to happen, which goes beyond the usual depression.
  2. Melancholic depression: A subgroup characterized by an almost total loss of the ability to feel joy in all or almost all activities, a deeper sense of sadness or depression, often worse in the morning, as well as other specific symptoms such as excessive or inappropriate guilt.
  3. Atypical depression: Characterized by the ability to feel better in response to positive events temporarily, increased appetite or weight gain, excessive drowsiness or sleep, a heavy feeling in the arms or legs, and a prolonged feeling of rejection.
  4. Seasonal depression: A form of depression that occurs at the same time each year, usually during fall and winter when there is less daylight.
  5. Peripartum depression: Formerly known as postpartum depression, this is depression that occurs during pregnancy or after childbirth and affects a woman’s ability to function.
  6. Psychotic depression: A severe form of depression where the individual also experiences some form of psychosis, such as delusions or hallucinations, often with themes of guilt, illness or worthlessness. This may be related to other mental health problems.

The definition of the specific form can inform a more detailed diagnosis and understanding of the depression, which can guide treatment choices and prognosis. Each subgroup has its unique characteristics and may require different treatment strategies to manage symptoms effectively.

Treatment for clinical depression

Treatment for clinical depression is tailored to the individual and may include psychotherapy, such as Cognitive Behavioural Therapy and Interpersonal Therapy, to address negative thought patterns and behaviours and to improve social relationships. Antidepressants may also be used in combination with psychotherapy, for those with severe depression who do not respond to other treatments, Electroconvulsive Therapy (ECT) or Transcranial Magnetic Stimulation (TMS) may be offered. This is done in a psychiatric setting.

Lifestyle changes, including regular exercise, a balanced diet, good sleep hygiene, and stress management techniques such as mindfulness, can also help relieve depression symptoms. A combination of these treatment methods is often the most effective, and it is essential to receive treatment from qualified professionals to tailor treatment to the individual’s needs.


12 FAQs about Clinical Depression

What is clinical depression?

Clinical depression is a mental illness characterized by a deep and persistent sense of sadness or loss of interest in previously enjoyable activities.

What are the most common symptoms of clinical depression?

The most common symptoms include persistent sadness, lack of energy, sleep problems, fatigue and irritability.

How is clinical depression diagnosed?

Diagnosis of clinical depression is usually done through interviews and assessment forms by a health professional such as a psychologist or doctor. Blood tests are also often taken to rule out other medical causes.

What causes clinical depression?

Depression is a complex illness that is often caused by a combination of genetic, biological, environmental and psychological factors.

How is clinical depression treated?

Treatment options vary but often include therapy, medication and lifestyle changes. Cognitive Behavioural Therapy (CBT) is a common form of psychological treatment.

How long is the treatment for clinical depression?

The length of treatment can vary depending on the severity and individual needs. Some people can experience relief within a few weeks, while others need more prolonged treatment.

Is clinical depression hereditary?

Genetics can play a role in depression, but it is usually a combination of several factors that contribute to the illness.

Can exercise help with clinical depression?

Yes, regular physical activity can help, but more intervention is often needed, and physical activity should not replace professional care when needed.

What are the risk factors for clinical depression?

The risk factors for clinical depression are multiple and include a combination of genetic, biological, environmental and psychological elements, so it can be difficult to predict.

What is the difference between major depression and clinical depression?

Both terms describe the diagnosis of Major Depressive Disorder (MDD), but Major Depression is episodic and is often used as a medical term to distinguish it from other illnesses, such as bipolar disorder. In contrast, clinical depression is a term used to describe that depression requires clinical care.

How does clinical depression affect relationships?

Depression can make it challenging to maintain healthy relationships and can lead to social withdrawal. You may have less interest in being social.

Where can I get help?

If you experience symptoms of depression, it is essential to seek professional help. Our psychologists and therapists are available for online or face-to-face sessions and can help you make the difficult things more accessible. If you have thoughts of self-harm or suicidal thoughts, contact SADAG at 0800 567 567 or the nearest emergency room.

Step-by-step treatment for clinical depression

Treatment for clinical depression is individualized and may include a combination of the following strategies:

  1. Psychotherapy: Also known as talk therapy, Cognitive Behavioural Therapy (CBT) and Interpersonal Therapy (IPT) are among the most effective forms. CBT focuses on identifying and changing negative thought patterns and behaviours that contribute to depression, while IPT focuses on improving the person’s relationships and social functioning.
  2. Antidepressant medication: These medications can help adjust the chemical imbalances in the brain that contribute to depression. There are several different classes of antidepressants. The choice of medication depends on the patient’s symptoms, possible side effects, and other health conditions.
  3. Electroconvulsive Therapy (ECT): For people with severe depression who do not respond to medication or psychotherapy, ECT can be a practical option. ECT involves passing electrical currents through the brain to trigger a brief seizure, which appears to adjust brain chemistry.
  4. Transcranial Magnetic Stimulation (TMS): A newer treatment method that uses magnetic fields to stimulate certain brain parts. It is effective for some people with depression.
  5. Lifestyle changes: Regular physical activity, a nutritious diet, adequate sleep, and stress management techniques such as mindfulness and meditation can improve symptoms of depression.

The choice of treatment depends on the severity of the depression, the patient’s preferences, previous treatment results, and any co-existing medical conditions. A combination of treatments is often the most effective. It is essential to open dialogue with your healthcare provider to find the best treatment for each individual.


Written by Samantha Pieterse

Sr. Samantha Pieterse is a registered psychiatric nurse who is deeply committed to mental health and well-being. Samantha brings a unique and valuable perspective to her role as an editor for Lavendla South Africa. She has worked in Government and Private mental healthcare institutions in Gauteng and her expertise ensures that the articles on our website are accurate and accessible. Samantha is dedicated to enhancing mental health awareness and education in South Africa.